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Refractometric biosensing based on optical phase flips in sparse and short-range-ordered nanoplasmonic layers
Chalmers University of Technology, Sweden.
2014 (English)In: Light: Science & Applications, ISSN 2095-5545, E-ISSN 2047-7538, ISSN ´, Vol. 3, article id e220Article in journal (Refereed) Published
Abstract [en]

Noble metal nanoparticles support localized surface plasmon resonances (LSPRs) that are extremely sensitive to the local dielectric properties of the environment within distances up to 10-100[emsp14]nm from the metal surface. The significant overlap between the sensing volume of the nanoparticles and the size of biological macromolecules has made LSPR biosensing a key field for the application of plasmonics. Recent advancements in evaluating plasmonic refractometric sensors have suggested that the phase detection of light can surpass the sensitivity of standard intensity-based detection techniques. Here, we experimentally confirm that the phase of light can be used to precisely track local refractive index changes induced by biomolecular reactions, even for dilute and layers of short-range-ordered plasmonic nanoparticles. In particular, we demonstrate that the sensitivity can be enhanced by tuning in to a zero reflection condition, in which an abrupt phase flip of the reflected light is achieved. Using a cost-effective interference fringe tracking technique, we demonstrate that phase measurements yield an approximately one order of magnitude larger relative shift compared with traditional LSPR measurements for the model system of NeutrAvidin binding to biotinylated nanodisks.

Place, publisher, year, edition, pages
Nature Publishing Group, 2014. Vol. 3, article id e220
Keywords [en]
biosensors, interferometry, metasurfaces, nanostructures, spectroscopy
National Category
Nano Technology Atom and Molecular Physics and Optics Other Physics Topics
Research subject
Physics
Identifiers
URN: urn:nbn:se:kth:diva-197587DOI: 10.1038/lsa.2014.101OAI: oai:DiVA.org:kth-197587DiVA, id: diva2:1165962
Note

QC 20171214

Available from: 2017-12-14 Created: 2017-12-14 Last updated: 2017-12-14Bibliographically approved

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