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Ultrahigh sensitivity made simple: nanoplasmonic label-free biosensing with an extremely low limit-of-detection for bacterial and cancer diagnostics.
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2009 (English)In: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 20, no 43Article in journal (Refereed) Published
Abstract [en]

We present a simple and robust scheme for biosensing with an ultralow limit-of-detection down to several pg cm(-2) (or several tens of attomoles cm(-2)) based on optical label-free biodetection with localized surface plasmon resonances. The scheme utilizes cost-effective optical components and comprises a white light source, a properly functionalized sensor surface enclosed in a simple fluidics chip, and a spectral analyzer. The sensor surface is produced by a bottom-up nanofabrication technique with hole mask colloidal lithography. Despite its simplicity, the method is able to reliably detect protein-protein binding events at low picomolar and femtomolar concentrations, which is exemplified by the label-free detection of the extracellular adherence protein (EAP) found on the outer surface of the bacterium Staphylococcus aureus and of prostate-specific antigen (PSA), which is believed to be a prostate cancer marker. These experiments pave the way towards an ultra-sensitive yet compact biodetection platform for point-of-care diagnostics applications.

Place, publisher, year, edition, pages
Institute of Physics (IOP), 2009. Vol. 20, no 43
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Nano Technology Atom and Molecular Physics and Optics Other Physics Topics
Research subject
Physics
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URN: urn:nbn:se:kth:diva-197585DOI: 10.1088/0957-4484/20/43/434015PubMedID: 19801769Scopus ID: 2-s2.0-70349658865OAI: oai:DiVA.org:kth-197585DiVA, id: diva2:1165968
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QC 20171218

Available from: 2017-12-14 Created: 2017-12-14 Last updated: 2017-12-18Bibliographically approved

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