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Insights into the EDC-mediated PEGylation of cellulose nanofibrils and their colloidal stability
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology. KTH, School of Chemical Science and Engineering (CHE), Centres, Wallenberg Wood Science Center.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology. KTH, School of Chemical Science and Engineering (CHE), Centres, Wallenberg Wood Science Center.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology. KTH, School of Chemical Science and Engineering (CHE), Centres, Wallenberg Wood Science Center.
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2018 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 181, 871-878 p.Article in journal (Refereed) Published
Abstract [en]

EDC-mediated coupling has frequently been utilized to poly(ethylene glycol) functionalize (PEGylate) cellulose-based materials, but no work has previously been reported on the direct N-(3-dimethylaminopropyl)-N-ethylcarbodiimide (EDC)-mediated PEGylation of cellulose nanofibrils (CNF). Herein, we report the first study where CNF has been directly sterically stabilized with amine-terminated PEG employing N-hydroxysuccinimide (NHS)-assisted EDC-coupling. This work has shown that this coupling reaction is highly sensitive to the reaction conditions and purification procedures, and hence an optimized coupling protocol was developed in order to achieve a reaction yield. Elemental analysis of the nitrogen content also showed the successful PEGylation. It was also shown that a surprisingly low PEGylation (1%) is sufficient to significantly improve the colloidal stability of the PEGylated samples, which reached dispersion-arrested-state-transitions at higher concentrations than neat CNF. The colloidal stability was preserved with increasing ionic strength, when comparably long polymer chains were grafted, targeting only 1% PEGylation.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 181, 871-878 p.
Keyword [en]
Cellulose nanofibrils, Colloidal stability, PEGylation, Steric stabilization
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-220410DOI: 10.1016/j.carbpol.2017.11.065ISI: 000418661000101PubMedID: 29254048Scopus ID: 2-s2.0-85037689178OAI: oai:DiVA.org:kth-220410DiVA: diva2:1168201
Note

QC 20171220

Available from: 2017-12-20 Created: 2017-12-20 Last updated: 2018-01-11Bibliographically approved

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Kaldéus, TahaniNordenström, Malin

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