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Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells
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2017 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 12, article id e0188772Article in journal (Refereed) Published
Abstract [en]

The cell cycle coordinates core functions such as replication and cell division. However, cell-cycle-regulated transcription in the control of non-core functions, such as cell identity maintenance through specific transcription factors (TFs) and signalling pathways remains unclear. Here, we provide a resource consisting of mapped transcriptomes in unsynchro-nized HeLa and U2OS cancer cells sorted for cell cycle phase by Fucci reporter expression. We developed a novel algorithm for data analysis that enables efficient visualization and data comparisons and identified cell cycle synchronization of Notch signalling and TFs associated with development. Furthermore, the cell cycle synchronizes with the circadian clock, providing a possible link between developmental transcriptional networks and the cell cycle. In conclusion we find that cell cycle synchronized transcriptional patterns are temporally compartmentalized and more complex than previously anticipated, involving genes, which control cell identity and development.

Place, publisher, year, edition, pages
Public Library of Science , 2017. Vol. 12, no 12, article id e0188772
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Biological Sciences
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URN: urn:nbn:se:kth:diva-220599DOI: 10.1371/journal.pone.0188772ISI: 000417648600013Scopus ID: 2-s2.0-85038411630OAI: oai:DiVA.org:kth-220599DiVA, id: diva2:1174280
Note

QC 20180115

Available from: 2018-01-15 Created: 2018-01-15 Last updated: 2018-01-15Bibliographically approved

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Lundberg, Emma

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Science for Life Laboratory, SciLifeLabAlbanova VinnExcellence Center for Protein Technology, ProNova
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