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Resolving a Reactive Organometallic Intermediate from Dynamic Directing Group Systems by Selective C-H Activation
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry.ORCID iD: 0000-0001-5298-4310
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry.
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry.
2018 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 24, no 1, p. 101-104Article in journal (Refereed) Published
Abstract [en]

Catalyst discovery from systems of potential precursors is a challenging endeavor. Herein, a new strategy applying dynamic chemistry to the identification of catalyst precursors from C-H activation of imines is proposed and evaluated. Using hydroacylation of imines as a model reaction, the selection of an organometallic reactive intermediate from a dynamic imine system, involving many potential directing group/metal entities, is demonstrated. The identity of the amplified reaction intermediate with the best directing group could be resolved in situ by ESI-MS, and coupling of the procedure to an iterative deconvolution protocol generated a system with high screening efficiency.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2018. Vol. 24, no 1, p. 101-104
Keywords [en]
catalysis, C-H activation, directing group, dynamic chemistry, systems chemistry
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-221349DOI: 10.1002/chem.201705273ISI: 000419046600016PubMedID: 29149517Scopus ID: 2-s2.0-85039907333OAI: oai:DiVA.org:kth-221349DiVA, id: diva2:1175023
Funder
Swedish Research CouncilEU, FP7, Seventh Framework Programme, 289033
Note

QC 20180117

Available from: 2018-01-17 Created: 2018-01-17 Last updated: 2018-01-17Bibliographically approved

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Schaufelberger, FredrikRamström, Olof

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CiteExportLink to record
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