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Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Wallenberg Wood Science Center.
2017 (English)In: Journal of Pharmacy and Pharmacology (JPP), ISSN 0022-3573, E-ISSN 2042-7158, Vol. 69, no 11, p. 1477-1484Article in journal (Refereed) Published
Abstract [en]

Objectives: This study aimed to prepare a furosemide-loaded sustained release cellulose nanofibre (CNF)-based nanofoams with buoyancy. Methods: Dry foams consisting of CNF and the model drug furosemide at concentrations of 21% and 50% (w/w) have been prepared by simply foaming a CNF-drug suspension followed by drying. The resulting foams were characterized towards their morphology, solid state properties and dissolution kinetics. Key findings: Solid state analysis of the resulting drug-loaded foams revealed that the drug was present as an amorphous sodium furosemide salt and in form of furosemide form I crystals embedded in the CNF foam cell walls. The foams could easily be shaped and were flexible, and during the drug release study, the foam pieces remained intact and were floating on the surface due to their positive buoyancy. Both foams showed a sustained furosemide release compared to a marketed tablet. It was found that the extent of sustained release from both foams was dependent on the drug loading, the dimension of the foam piece, as well as the solid state of the drug. Conclusions: Furosemide-loaded CNF-based foams with sustained release and buoyancy have been successfully prepared in a simple casting and drying procedure.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2017. Vol. 69, no 11, p. 1477-1484
Keywords [en]
cellular solid material, cellulose nanofibres, foam, furosemide, sustained release, cellulose nanofiber, furosemid ratiopharm, nanofiber, sodium, unclassified drug, Article, controlled study, crystal, dissolution, drug bioavailability, drug dosage form comparison, foaming, particle size, physical chemistry, solid state, surface property, suspension, sustained drug release, sustained release preparation, tablet
National Category
Medical Materials
Identifiers
URN: urn:nbn:se:kth:diva-218841DOI: 10.1111/jphp.12793ISI: 000412309100007Scopus ID: 2-s2.0-85030626847OAI: oai:DiVA.org:kth-218841DiVA, id: diva2:1176330
Note

QC 20180122

Available from: 2018-01-22 Created: 2018-01-22 Last updated: 2018-01-22Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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More styles
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  • de-DE
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  • Other locale
More languages
Output format
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