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The Human Cell Atlas
KTH, School of Biotechnology (BIO), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0001-7034-0850
KTH, School of Biotechnology (BIO), Protein Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab. Danish Tech Univ, Denmark.ORCID iD: 0000-0001-8993-048X
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Number of Authors: 612017 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 6, article id e27041Article in journal (Refereed) Published
Abstract [en]

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

Place, publisher, year, edition, pages
ELIFE SCIENCES PUBLICATIONS LTD , 2017. Vol. 6, article id e27041
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Physical Sciences
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URN: urn:nbn:se:kth:diva-222115DOI: 10.7554/eLife.27041ISI: 000419858100001Scopus ID: 2-s2.0-85040459896OAI: oai:DiVA.org:kth-222115DiVA, id: diva2:1179254
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QC 20180131

Available from: 2018-01-31 Created: 2018-01-31 Last updated: 2018-01-31Bibliographically approved

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Lundberg, EmmaUhlén, Mathias

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