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In vitro fermentation of Cookeina speciosa glucans stimulates the growth of the butyrogenic Clostridium cluster XIVa in a targeted way
KTH, School of Biotechnology (BIO), Glycoscience. Universidade Federal do ParanĂ¡, Brazil.
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2018 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 183, p. 219-229Article in journal (Refereed) Published
Abstract [en]

Dietary fiber chemical and physical structures may be critical to the comprehension of how they may modulate gut bacterial composition. We purified insoluble polymers from Cookeina speciosa, and investigated its fermentation profile in an in vitro human fecal fermentation model. Two glucans, characterized as a (1 -> 3),(1 -> 6)-linked and a (1 -> 3)-linked beta-D-glucans were obtained. Both glucans were highly butyrogenic and propiogenic, with low gas production, during in vitro fecal fermentation and led to distinct bacterial shifts if compared to fructooligosaccharides. Specific increases in Bacteroides uniformis and genera from the Clostridium cluster XIVa, such as butyrogenic Anaerostipes and Roseburia were observed. The (1 -> 3)-linked beta-D-glucan presented a faster fermentation profile compared to the branched (1 -> 3),(1 -> 6)-linked beta-D-glucan. Our findings support the view that depending on its fine chemical structure, and likely its insoluble nature, these dietary fibers can be utilized to direct a targeted promotion of the intestinal microbiota to butyrogenic Clostridium cluster XIVa bacteria.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 183, p. 219-229
Keywords [en]
Butyrate, Cookeina speciose, Clostridium cluster XIVa, Glucans, In vitro fecal fermentation
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-223253DOI: 10.1016/j.carbpol.2017.12.020ISI: 000423715000023PubMedID: 29352878Scopus ID: 2-s2.0-85038211086OAI: oai:DiVA.org:kth-223253DiVA, id: diva2:1183763
Note

QC 20180219

Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2018-02-19Bibliographically approved

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CiteExportLink to record
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