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High-resolution dynamic computer simulation of electrophoresis using a multiphysics software platform
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemical Engineering, Applied Electrochemistry. COMSOL AB, Sweden.
2018 (English)In: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 1532, p. 216-222Article in journal (Refereed) Published
Abstract [en]

The modeling and simulation software COMSOL Multiphysics (R) was recently extended with an electrophoretic transport interface. Its performance was investigated by comparison to results obtained using the 1D dynamic electrophoresis simulators GENTRANS and SIMUL5. Simulations of zone electrophoresis, isotachophoresis, isoelectric focusing and of an oscillating electrolyte system were performed. Smooth profiles were essentially identical indicating that the COMSOL electrophoretic transport interface is able to reproduce results of the 1D simulators. Differences in the way the respective numerical schemes handle steep concentration gradients and associated instabilities were observed. The COMSOL electrophoretic transport interface is expected to be useful as a general model for simulations in 1D, 2D or 3D geometries, as well as for simulations combining electrophoresis with other physical phenomena.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 1532, p. 216-222
Keywords [en]
Computer simulation, COMSOL multiphysics, Electrophoresis, Isoelectric focusing, Isotachophoresis, Zone electrophoresis
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-223284DOI: 10.1016/j.chroma.2017.11.060ISI: 000423894500024PubMedID: 29191404Scopus ID: 2-s2.0-85035202883OAI: oai:DiVA.org:kth-223284DiVA, id: diva2:1183770
Conference
45th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC), JUN 18-22, 2017, Prague, Czech Republic
Note

QC 20180219

Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2018-02-28Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
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Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
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  • Other locale
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Output format
  • html
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