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Broad Views of Non-alcoholic Fatty Liver Disease
KTH, Centres, Science for Life Laboratory, SciLifeLab.
2018 (English)In: CELL SYSTEMS, ISSN 2405-4712, Vol. 6, no 1, p. 7-9Article in journal, Editorial material (Other academic) Published
Abstract [en]

Multi-omics multi-tissue data are used to interpret genome-wide association study results from mice to identify key driver genes of non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease (NAFLD) is the accumulation of fat (steatosis) in the liver due to causes other than excessive alcohol consumption. The disease may progress to more severe forms of liver diseases, including non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. In this issue of Cell Systems, Krishnan et al. (2018) reveal mechanisms underlying NAFLD by generating multi-omics data using liver and adipose tissues obtained from the Hybrid Mouse Diversity Panel, consisting of 113 mouse strains with various degrees of NAFLD. The study identified key driver genes of NAFLD that can be used in the development of efficient treatment strategies and illustrates the potential utility of systematic analysis of multi-layer biological networks.

Place, publisher, year, edition, pages
CELL PRESS , 2018. Vol. 6, no 1, p. 7-9
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Genetics
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URN: urn:nbn:se:kth:diva-222420DOI: 10.1016/j.cels.2018.01.004ISI: 000423444900004Scopus ID: 2-s2.0-85041659728OAI: oai:DiVA.org:kth-222420DiVA, id: diva2:1186394
Note

QC 20180228

Available from: 2018-02-28 Created: 2018-02-28 Last updated: 2018-02-28Bibliographically approved

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Mardinoglu, Adil

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