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Current applications of antibody microarrays
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Affinity Proteomics. KTH, Centres, Science for Life Laboratory, SciLifeLab.
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Affinity Proteomics. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0001-8141-8449
2018 (English)In: Clinical Proteomics, ISSN 1542-6416, E-ISSN 1559-0275, Vol. 15, article id 7Article, review/survey (Refereed) Published
Abstract [en]

The concept of antibody microarrays is one of the most versatile approaches within multiplexed immunoassay technologies. These types of arrays have increasingly become an attractive tool for the exploratory detection and study of protein abundance, function, pathways, and potential drug targets. Due to the properties of the antibody microarrays and their potential use in basic research and clinical analytics, various types of antibody microarrays have already been developed. In spite of the growing number of studies utilizing this technique, few reviews about antibody microarray technology have been presented to reflect the quality and future uses of the generated data. In this review, we provide a summary of the recent applications of antibody microarray techniques in basic biology and clinical studies, providing insights into the current trends and future of protein analysis.

Place, publisher, year, edition, pages
BioMed Central, 2018. Vol. 15, article id 7
Keywords [en]
Antibody microarray, Signalling, Drug mechanism, Clinical application, Systems biology, Technology advances
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-224692DOI: 10.1186/s12014-018-9184-2ISI: 000426761800001PubMedID: 29507545Scopus ID: 2-s2.0-85042706257OAI: oai:DiVA.org:kth-224692DiVA, id: diva2:1192435
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceKnut and Alice Wallenberg Foundation
Note

QC 20180322

Available from: 2018-03-22 Created: 2018-03-22 Last updated: 2018-03-22Bibliographically approved

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Dodig-Crnkovic, TeaSchwenk, Jochen M.

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