Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Sexual dimorphism in the width of the mouse synaptonemal complex
KTH, School of Engineering Sciences (SCI), Applied Physics. KTH, Centres, Science for Life Laboratory, SciLifeLab.
Show others and affiliations
2018 (English)In: Journal of Cell Science, ISSN 0021-9533, E-ISSN 1477-9137, Vol. 131, no 5, article id jcs212548Article in journal (Refereed) Published
Abstract [en]

Sexual dimorphism has been used to describe morphological differences between the sexes, but can be extended to any biologically related process that varies between males and females. The synaptonemal complex (SC) is a tripartite structure that connects homologous chromosomes in meiosis. Here, aided by superresolution microscopy techniques, we show that the SC is subject to sexual dimorphism, in mouse germ cells. We have identified a significantly narrower SC in oocytes and have established that this difference does not arise from a different organization of the lateral elements nor from a different isoform of transverse filament protein SYCP1. Instead, we provide evidence for the existence of a narrower central element and a different integration site for the C-termini of SYCP1, in females. In addition to these female-specific features, we speculate that post-translation modifications affecting the SYCP1 coiled-coil region could render a more compact conformation, thus contributing to the narrower SC observed in females.

Place, publisher, year, edition, pages
Company of Biologists Ltd , 2018. Vol. 131, no 5, article id jcs212548
Keywords [en]
Meiosis, SIM, STORM, Super-resolution microscopy, Synaptonemal complex
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-224822DOI: 10.1242/jcs.212548ISI: 000427877600011Scopus ID: 2-s2.0-85043782610OAI: oai:DiVA.org:kth-224822DiVA, id: diva2:1193293
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceSwedish Cancer Society, 170226EU, Horizon 2020, 634113Swedish Research Council, K2013-54X-21397-04-5Swedish Foundation for Strategic Research , RIF14-0091
Note

QC 20180326

Available from: 2018-03-26 Created: 2018-03-26 Last updated: 2018-04-11Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records BETA

Bernhem, Kristoffer

Search in DiVA

By author/editor
Bernhem, KristofferBlom, HansBrismar, Hjalmar
By organisation
Applied PhysicsScience for Life Laboratory, SciLifeLabBiophysics
In the same journal
Journal of Cell Science
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 25 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf