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An integrated all foil based micro device for point of care diagnostic applications
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.ORCID iD: 0000-0002-0242-358X
2018 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 259, p. 917-925Article in journal (Refereed) Published
Abstract [en]

Point-of-Care (POC) diagnostics often fail to meet the market requirements of low cost and advanced functionality, and are often limited to lateral flow based serological diagnostics with reduced sensitivity and specificity. We report here on an integrated microfluidic absorbance measurement device fabricated by roll-to-roll (R2R) compatible manufacturing processes, suitable for low cost POC systems. It is a device exclusively made of foils and takes external light from a low cost LED and converts the point light source to a homogeneous light via a foil based optical filter at the bottom of the device. The light is converted to an electrical signal by an amorphous organic semiconductor (OSC) material, integrated with screen-printed carbon finger on top of the device for electrical measurement. As a proof of principle, we demonstrate DNA hybridization assay, where the target DNA is coupled to magnetic beads for absorbance measurement. The device successfully distinguishes between matched and mismatched DNA hybridization and can differentiate between 1 μM, 50 nM and 2.5 nM DNA target concentrations. The inherent characteristics of the substrates and R2R fabrication concept significantly reduce the cost, making it suitable for POC applications at resource-limited settings. 

Place, publisher, year, edition, pages
Elsevier B.V. , 2018. Vol. 259, p. 917-925
Keywords [en]
DNA analysis, Microfluidics, Optical detection, Point-of-care, Amorphous carbon, Carbon, Costs, DNA, Light sources, Organic light emitting diodes (OLED), Substrates, Absorbance measurements, Dna hybridization assays, Inherent characteristics, Integrated microfluidics, Point of care, Point of care diagnostic, Cost reduction
National Category
Biological Sciences Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-223112DOI: 10.1016/j.snb.2017.12.133ISI: 000424877600111Scopus ID: 2-s2.0-85039735667OAI: oai:DiVA.org:kth-223112DiVA, id: diva2:1193681
Note

Export Date: 13 February 2018; Article; CODEN: SABCE; Correspondence Address: Russom, A.; Div of Proteomics and Nanobiotechnology, Science for Life Laboratory, KTH Royal Institute of TechnologySweden; email: aman.russom@scilifelab.se. QC 20180327

Available from: 2018-03-27 Created: 2018-03-27 Last updated: 2018-03-27Bibliographically approved

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Ohlander, AnnaRussom, Aman

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