Microalbuminuria and Left Ventricular Functions in Type 2 Diabetes: A Quantitative Assessment by Stress Echocardiography in the Myocardial Doppler in Diabetes (MYDID) Study III
2007 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 41, no 6, 363-369 p.Article in journal (Refereed) Published
Background. Left ventricular (LV) function might be altered in type 2 diabetes (DM) and microalbuminuria (MA) may accentuate the abnormalities. We sought to investigate whether additional LV dysfunction could be unmasked using tissue Doppler (TVE)-enhanced dobutamine stress echocardiography (TVE-DSE) in patients with DM+MA. Methods. Twenty seven DM subjects with MA, (DM+MA), 31 DM subjects without MA (DM-MA), and 13 Controls were evaluated using TVE-DSE. LV basal peak systolic (PSV), early (E') and late (A') diastolic velocities (cm/sec) at rest and peak stress were post-processed. LV filling pressure was assessed using E/E'ratio. Results. PSV and E'velocity at peak stress in the respective three groups were 13.7±1.0, 10.1±1.1, 10.0±1.2 for PSV; and 10.0±1.6, 5.0±1.4, 4.8±1.4 for E' (p < 0.001 for controls vs. both groups). E/E' at rest was 7.9±0.7 in the controls, 10.8±2.4 in DM-MA, and 11.0±2.2 in DM+MA (p < 0.01 Controls vs. both the DM groups). Conclusions. Patients with DM+MA do not have additional LV regional systolic and diastolic dysfunctions compared with DM-MA, as revealed by TVE-DSE, when controlled for glycemia levels, lipids, and treatment strategies.
Place, publisher, year, edition, pages
2007. Vol. 41, no 6, 363-369 p.
Left ventricular function; Microalbuminuria; Tissue velocity echocardiography; Type 2 diabetes
Endocrinology and Diabetes Cardiac and Cardiovascular Systems
IdentifiersURN: urn:nbn:se:kth:diva-7059DOI: 10.1080/14017430701604598ISI: 000251143200003PubMedID: 17924282ScopusID: 2-s2.0-41649083353OAI: oai:DiVA.org:kth-7059DiVA: diva2:11952
QC 201007092007-05-082007-05-082016-05-09Bibliographically approved