Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Synthetic antibodies in infectious disease
KTH, School of Biotechnology (BIO), Protein Technology. University of Toronto, Canada.
2017 (English)In: Recombinant Antibodies for Infectious Diseases, Springer-Verlag New York, 2017, p. 79-98Chapter in book (Refereed)
Abstract [en]

Rapid spread of microbial resistance and recent outbreaks of viral disease have led to renewed interest in antibody-based therapies for infectious diseases. Synthetic antibody libraries displayed on phage offer unique advantages over traditional immunization-based antibody generation, including full control over library design and selection conditions. The technology has matured beyond natural antibodies and is capable of providing novel insights into infectious disease and can generate novel antibodies that cannot be produced by the natural immune system. This chapter gives an overview of recombinant antibody library technology with an emphasis on our work using a highly successful synthetic single framework Fab library. We demonstrate its utility in targeting viruses and bacterial toxins in five case studies.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2017. p. 79-98
Series
Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 1053
Keywords [en]
Fab, In vitro selection, Phage display, Synthetic antibody
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:kth:diva-225516DOI: 10.1007/978-3-319-72077-7_5Scopus ID: 2-s2.0-85044262764ISBN: 978-3-319-72076-0 (print)OAI: oai:DiVA.org:kth-225516DiVA, id: diva2:1195669
Note

QC 20180406

Available from: 2018-04-06 Created: 2018-04-06 Last updated: 2018-04-06Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Nilvebrant, Johan
By organisation
Protein Technology
Immunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar

doi
isbn
urn-nbn

Altmetric score

doi
isbn
urn-nbn
Total: 6 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf