Modeling the impact of store-operated Ca2+ entry on intracellular Ca2+ oscillations
2006 (English)In: Mathematical biosciences, ISSN 0025-5564, Vol. 204, no 2, 232-249 p.Article in journal (Refereed) Published
Calcium (Ca2+) oscillations play fundamental roles in various cell signaling processes and have been the subject of numerous modeling studies. Here we have implemented a general mathematical model to simulate the impact of store-operated Ca2+ entry on intracellular Ca2+ oscillations. In addition, we have compared two different models of the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) and their influences on intracellular Ca2+ oscillations. Store-operated Ca2+ entry following Ca2+ depletion of endoplasmic reticulum (ER) is an important component of Ca2+ signaling. We have developed a phenomenological model of store-operated Ca2+ entry via store-operated Ca2+ (SOC) channels, which are activated upon ER Ca2+ depletion. The depletion evokes a bi-phasic Ca2+ signal, which is also produced in our mathematical model. The IP3R is an important regulator of intracellular Ca2+ signals. This IP3 sensitive Ca2+ channel is also regulated by Ca2+. We apply two IP3R models, the Mak-McBride-Foskett model and the De Young and Keizer model, with significantly different channel characteristics. Our results show that the two separate IP3R models evoke intracellular Ca2+ oscillations with different frequencies and amplitudes. Store-operated Ca2+ entry affects the oscillatory behavior of these intracellular Ca2+ oscillations. The IP3 threshold is altered when store-operated Ca2+ entry is excluded from the model. Frequencies and amplitudes of intracellular Ca2+ oscillations are also altered without store-operated Ca2+ entry. Under certain conditions, when intracellular Ca2+ oscillations are absent, excluding store-operated Ca2+ entry induces an oscillatory response. These findings increase knowledge concerning store-operated Ca2+ entry and its impact on intracellular Ca2+ oscillations.
Place, publisher, year, edition, pages
2006. Vol. 204, no 2, 232-249 p.
calcium; oscillation; SOC
Condensed Matter Physics
IdentifiersURN: urn:nbn:se:kth:diva-7064DOI: 10.1016/j.mbs.2006.03.001ISI: 000242902200005ScopusID: 2-s2.0-33750721337OAI: oai:DiVA.org:kth-7064DiVA: diva2:11960
QC 201007262007-05-082007-05-082010-12-06Bibliographically approved