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Risk Factors for Severe Acute Graft-versus-Host Disease in Donor Graft Composition
Karolinska Inst, Dept Oncol Pathol, SE-14186 Stockholm, Sweden..
Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden..
Karolinska Inst, Dept Lab Med, Stockholm, Sweden..
Karolinska Inst, Dept Oncol Pathol, SE-14186 Stockholm, Sweden..
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2018 (English)In: Biology of blood and marrow transplantation, ISSN 1083-8791, E-ISSN 1523-6536, Vol. 24, no 3, p. 467-477Article in journal (Refereed) Published
Abstract [en]

Acute graft-versus-host disease (aGVHD) is 1 of the main major complications of post-hematopoietic stem cell transplantation (HSCT). Identifying patients at risk of severe aGVHD may lead to earlier intervention and treatment, resulting in increased survival and a better quality of life. We aimed to identify biomarkers in donor grafts and patient plasma around the time of transplantation that might be predictive of aGVHD development. We build on our previously published methods by using multiplex assays and multicolor flow cytometry. We identified 5 easily assessable cellular markers in donor grafts that combined could potentially be used to calculate risk for severe aGVHD development. Most noteworthy are the T cell subsets expressing IL-7 receptor-a (CD127) and PD-1. Additionally, we identified a potential role for elevated tumor necrosis factor-a levels in both graft and patient before HSCT in development of aGVHD. 

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC , 2018. Vol. 24, no 3, p. 467-477
Keywords [en]
Stem cell transplantation, GVHD, T cells, Donor grafts, Risk factors
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:kth:diva-225738DOI: 10.1016/j.bbmt.2017.11.026ISI: 000427663000008PubMedID: 29197674OAI: oai:DiVA.org:kth-225738DiVA, id: diva2:1196481
Funder
Swedish Research CouncilStockholm County CouncilSwedish Foundation for Strategic Research
Note

QC 20180410

Available from: 2018-04-10 Created: 2018-04-10 Last updated: 2018-04-10Bibliographically approved

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Önfelt, BjörnUhlin, Michael

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