Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Subpixel x-ray imaging with an energy-resolving detector
KTH, School of Engineering Sciences (SCI), Physics, Physics of Medical Imaging. Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA..ORCID iD: 0000-0002-5092-8822
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neuroradiol, Stockholm, Sweden..
KTH, School of Engineering Sciences (SCI), Physics.
Show others and affiliations
2018 (English)In: Journal of Medical Imaging, ISSN 2329-4302, E-ISSN 2329-4310, Vol. 5, no 1, article id 013507Article in journal (Refereed) Published
Abstract [en]

The detector pixel size can be a severe limitation in x-ray imaging of fine details in the human body. We demonstrate a method of using spectral x-ray measurements to image the spatial distribution of the linear attenuation coefficient on a length scale smaller than one pixel, based on the fact that interfaces parallel to the x-ray beam have a unique spectral response, which distinguishes them from homogeneous materials. We evaluate the method in a simulation study by simulating projection imaging of the border of an iodine insert with 200 mg/ml I in a soft tissue phantom. The results show that the projected iodine profile can be recovered with an RMS resolution of 5% to 34% of the pixel size, using an ideal energy-resolving detector. We also validate this method in an experimental study by imaging an iodine insert in a polyethylene phantom using a photon-counting silicon-strip detector. The results show that abrupt and gradual transitions can be distinguished based on the transmitted x-ray spectrum, in good agreement with simulations. The demonstrated method may potentially be used for improving visualization of blood vessel boundaries, e.g., in acute stroke care.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2018. Vol. 5, no 1, article id 013507
Keywords [en]
x-ray imaging, subpixel information, spectral x-ray imaging, photon-counting detector, partial volume effect
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-226818DOI: 10.1117/1.JMI.5.1.013507ISI: 000429258000030PubMedID: 29564367Scopus ID: 2-s2.0-85044647808OAI: oai:DiVA.org:kth-226818DiVA, id: diva2:1203552
Funder
VINNOVA, 2014-03800Stockholm County Council, 20140712
Note

QC 20180503

Available from: 2018-05-03 Created: 2018-05-03 Last updated: 2018-05-03Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Persson, MatsBornefalk, HansDanielsson, Mats

Search in DiVA

By author/editor
Persson, MatsBornefalk, HansDanielsson, Mats
By organisation
Physics of Medical ImagingPhysics
In the same journal
Journal of Medical Imaging
Radiology, Nuclear Medicine and Medical Imaging

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 3 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf