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Targeted and imaging-guided in vivo photodynamic therapy for tumors using dual-function, aggregation-induced emission nanoparticles
Zhejiang Univ, Ctr Opt & Electromagnet Res, State Key Lab Modern Opt Instrumentat, Hangzhou 310058, Zhejiang, Peoples R China..
Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Urol, Coll Med, Hangzhou 310016, Zhejiang, Peoples R China..
Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Labs Organ Solids & Analyt Chem Living Bi, Beijing 100190, Peoples R China..
Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Urol, Coll Med, Hangzhou 310016, Zhejiang, Peoples R China..
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2018 (English)In: Nano Reseach, ISSN 1998-0124, E-ISSN 1998-0000, Vol. 11, no 5, p. 2756-2770Article in journal (Refereed) Published
Abstract [en]

Imaging-guided photodynamic therapy (PDT) has been regarded as a promising strategy for precise cancer treatment. Because of their excellent modifiability and drug-loading capacity, nanoparticles have played an important role in PDT. Nonetheless, when traditional photosensitizers are made into nanoparticles, both their fluorescence and reactive oxygen species generation efficacy decrease due to a phenomenon known as aggregation-caused quenching. Fortunately, in recent years, several kinds of organic dyes with "abnormal" properties (termed aggregation-induced emission, AIE) were developed. With enhanced fluorescence emission in the nanoaggregation state, the traditional obstacles mentioned above may be overcome by AIE luminogens. Herein, we provide a better combination of photosensitizers and nanoparticles, namely, dual-function AIE nanoparticles capable of producing reactive oxygen species, to implement targeted and imaging-guided in vivo PDT. Good contrast of in vivo imaging and obvious therapeutic efficacy were observed at a low dose of AIE nanoparticles and low irradiance of light, thus resulting in negligible side effects. Our work shows that AIE nanoparticles may play a promising role in imaging-guided clinical PDT for cancer in the near future.

Place, publisher, year, edition, pages
Tsinghua University Press, 2018. Vol. 11, no 5, p. 2756-2770
Keywords [en]
aggregation-induced emission, targeted therapy, imaging-guided therapy, photodynamic therapy, tumor
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-229020DOI: 10.1007/s12274-017-1906-7ISI: 000431999700040Scopus ID: 2-s2.0-85035081256OAI: oai:DiVA.org:kth-229020DiVA, id: diva2:1211775
Note

QC 20180531

Available from: 2018-05-31 Created: 2018-05-31 Last updated: 2018-10-19Bibliographically approved

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