The impact of the distribution of isoforms on CaMKII activation
2006 (English)In: Neurocomputing, ISSN 0925-2312, Vol. 69, no 10-12, 1010-1013 p.Article in journal (Refereed) Published
We have developed a computational model of the regulation of alpha- and beta-CaMKII activity, in order to examine (i) the importance of neighbour subunit interactions and (ii) the effect the higher CaMCa4 affinity of beta-CaMKII has on the holoenzyme activity in different configurations with the same alpha: beta ratio. The model consists of a deterministic biochemical network coupled to stochastic activation of CaMKII The results suggest that CaMKII holoenzyme activity is non-linear and dependent on the holoenzyme configuration of isoforms. This is especially pronounced in situations with a high-dephosphorylation rate of CaMKII.
Place, publisher, year, edition, pages
2006. Vol. 69, no 10-12, 1010-1013 p.
CaMKII; Plasticity; Computer modelling; Stochastic model
IdentifiersURN: urn:nbn:se:kth:diva-7227DOI: 10.1016/j.neucom.2005.12.035ISI: 000237873900004ScopusID: 2-s2.0-33646520327OAI: oai:DiVA.org:kth-7227DiVA: diva2:12174
Hjorth, Johannes: Lic (Manuskript)
QC 201007232007-05-302007-05-302012-01-08Bibliographically approved