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Systems biology in hepatology: approaches and applications
KTH, Centres, Science for Life Laboratory, SciLifeLab. Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden..ORCID iD: 0000-0002-4254-6090
Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden..ORCID iD: 0000-0003-0786-8091
Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden..ORCID iD: 0000-0002-1439-4608
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden..ORCID iD: 0000-0001-8993-048X
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2018 (English)In: Nature Reviews. Gastroenterology & Hepatology, ISSN 1759-5045, E-ISSN 1759-5053, Vol. 15, no 6, p. 365-377Article, review/survey (Refereed) Published
Abstract [en]

Detailed insights into the biological functions of the liver and an understanding of its crosstalk with other human tissues and the gut microbiota can be used to develop novel strategies for the prevention and treatment of liver-associated diseases, including fatty liver disease, cirrhosis, hepatocellular carcinoma and type 2 diabetes mellitus. Biological network models, including metabolic, transcriptional regulatory, protein-protein interaction, signalling and co-expression networks, can provide a scaffold for studying the biological pathways operating in the liver in connection with disease development in a systematic manner. Here, we review studies in which biological network models were used to integrate multiomics data to advance our understanding of the pathophysiological responses of complex liver diseases. We also discuss how this mechanistic approach can contribute to the discovery of potential biomarkers and novel drug targets, which might lead to the design of targeted and improved treatment strategies. Finally, we present a roadmap for the successful integration of models of the liver and other human tissues with the gut microbiota to simulate whole-body metabolic functions in health and disease.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 15, no 6, p. 365-377
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:kth:diva-230482DOI: 10.1038/s41575-018-0007-8ISI: 000433166800010PubMedID: 29686404Scopus ID: 2-s2.0-85045834478OAI: oai:DiVA.org:kth-230482DiVA, id: diva2:1217741
Funder
Knut and Alice Wallenberg FoundationScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20180613

Available from: 2018-06-13 Created: 2018-06-13 Last updated: 2018-06-13Bibliographically approved

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Mardinoglu, AdilUhlén, MathiasNielsen, Jens

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