Modelling self-sustained rhythmic activity in lamprey hemisegmental networks
2006 (English)In: Neurocomputing, ISSN 0925-2312, Vol. 69, no 10-12, 1097-1102 p.Article in journal (Refereed) Published
Recent studies of the lamprey spinal cord have shown that hemisegmental preparations can display rhythmic activity in response to a constant input drive. This activity is believed to be generated by a network of recurrently connected excitatory interneurons. A recent study found and characterized self-sustaining rhythmic activity-locomotor bouts-after brief electrical stimulation of hemisegmental preparations. The mechanisms behind the bouts are still unclear. We have developed a computational model of the hemisegmental network. The model addresses the possible involvement of NMDA, AMPA, acetylcholine, and metabotropic glutamate receptors as well as axonal delays in locomotor bouts.
Place, publisher, year, edition, pages
2006. Vol. 69, no 10-12, 1097-1102 p.
CPG; Excitatory interneuron; Network simulations; Self-sustaining activity
IdentifiersURN: urn:nbn:se:kth:diva-7264DOI: 10.1016/j.neucom.2005.12.053ISI: 000237873900022ScopusID: 2-s2.0-33646096740OAI: oai:DiVA.org:kth-7264DiVA: diva2:12222
QC 20100715. Conference: 14th Annual Computational Neuroscience Meeting (CNS 05). Madison, WI. JUL 17-21, 20052007-06-012007-06-012011-10-04Bibliographically approved