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Human Cell Encapsulation in Gel Microbeads with Cosynthesized Concentric Nanoporous Solid Shells
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.ORCID iD: 0000-0002-9418-452X
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.ORCID iD: 0000-0002-0441-6893
Karolinska Univ Hosp, Dept Clin Sci Intervent & Technol, Novum Hiss 6A, S-14196 Huddinge, Sweden..
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.ORCID iD: 0000-0002-3549-0228
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2018 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 28, no 21, article id 1707129Article in journal (Refereed) Published
Abstract [en]

Encapsulation of therapeutic cells in core-shell microparticles has great promise for the treatment of a range of health conditions. Unresolved challenges related to control of the particle morphology, mechanical stability, and immunogenicity hinder dissemination of this promising approach. Here, a novel polymer material for cell encapsulation and a combined novel, easy to control, synthesis method are introduced. Core-shell cell encapsulation is demonstrated with a concentric core-shell morphology formed during a single UV exposure, resulting in particles that consist of a synthetic hydrogel core of polyethylene glycol diacrylate and a solid, but porous, shell of off-stoichiometric thiol-ene. The encapsulated human cells in 100 mu m diameter particles have >90% viability. The average shell thickness is controlled between 7 and 13 mu m by varying the UV exposure, and the shell is measured to be permeable to low molecular weight species (<180 Da) but impermeable to higher molecular weight species (>480 Da). The unique material properties and the orthogonal control of the microparticle core size, shell thickness, shell permeability, and shell surface properties address the key unresolved challenges in the field, and are expected to enable faster translation of novel cell therapy concepts from research to clinical practice.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2018. Vol. 28, no 21, article id 1707129
Keywords [en]
cell encapsulation, cell therapy, droplet microfluidics, off-stoichiometry thiol-ene polymers, OSTE, PEGDA, poly(ethylene glycol) diacrylate
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-231217DOI: 10.1002/adfm.201707129ISI: 000434030500006Scopus ID: 2-s2.0-85045190003OAI: oai:DiVA.org:kth-231217DiVA, id: diva2:1228551
Note

QC 20180628

Available from: 2018-06-28 Created: 2018-06-28 Last updated: 2018-06-28Bibliographically approved

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Zhou, XiamoHaraldsson, Klas TommyRibet, Federicovan der Wijngaart, Wouter Metsola

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