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Extrudering och 3D-skrivare: En enkel och billig process för tillverkning av matriser
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH).
2018 (Swedish)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
Extrusion and 3D-printing: A cheap and easy process for scaffold fabrication (English)
Abstract [en]

Aliphatic polyesters such as poly(lactide) (PLA), poly(glycolide) (PGA), poly(Ɛ-caprolactone)(PCL) and their copolymers have gained an intense interest for their implementation for tissueregeneration and medical applications because of their unique properties such asbiocompatibility, degradability and easy processing. This master thesis was focused on thefabrication of degradable porous scaffolds for soft tissue regeneration. For this purpose, a twostepprocess was optimized using PLA and PCL: melt-extrusion following 3D printing.In the melt-extrusion optimization, filaments with a specific diameter were fabricated by alab extruder and in-house made winder. To achieve this, extrusion parameters wereadjusted according to the thermal behavior of the polymer. Filaments with a regular diameter forfeeding a commercial 3D printer were produced using PLA and PCL. The printability wasassessed using the produced filaments as well as commercially available filaments. Twodifferent scaffold designs were 3D printed to check how the mechanical properties can be varied.Molecular weight, mechanical and thermal properties were respectively characterized bysize exclusion chromatography (SEC), tensile tests, differential scanning calorimetry (DSC)and thermogravimetric analysis (TGA) for the filaments and scaffoldsfabricated.

Place, publisher, year, edition, pages
2018.
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-231563OAI: oai:DiVA.org:kth-231563DiVA, id: diva2:1229241
Available from: 2018-06-29 Created: 2018-06-29 Last updated: 2018-06-29Bibliographically approved

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