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Short-Term Plasticity Combines with Excitation-Inhibition Balance to Expand Cerebellar Purkinje Cell Dynamic Range
Univ Strasbourg, CNRS, Inst Neurosci Cellulaires & Integrat, F-67084 Strasbourg, France..
Univ Strasbourg, CNRS, Inst Neurosci Cellulaires & Integrat, F-67084 Strasbourg, France.;UCL, Dept Neurosci Physiol & Pharmacol, London, England..ORCID iD: 0000-0002-0230-9752
KTH, School of Electrical Engineering and Computer Science (EECS).ORCID iD: 0000-0002-8044-9195
Univ Strasbourg, CNRS, Inst Neurosci Cellulaires & Integrat, F-67084 Strasbourg, France..ORCID iD: 0000-0002-0630-5935
2018 (English)In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 38, no 22, p. 5153-5167Article in journal (Refereed) Published
Abstract [en]

The balance between excitation (E) and inhibition (I) in neuronal networks controls the firing rate of principal cells through simple network organization, such as feedforward inhibitory circuits. Here, we demonstrate in male mice, that at the granule cell (GrC)molecular layer interneuron (MLI)-Purkinje cell (PC) pathway of the cerebellar cortex, E/I balance is dynamically controlled by short-term dynamics during bursts of stimuli, shaping cerebellar output. Using a combination of electrophysiological recordings, optogenetic stimulation, and modeling, we describe the wide range of bidirectional changes in PC discharge triggered by GrC bursts, from robust excitation to complete inhibition. At high frequency (200 Hz), increasing the number of pulses in a burst (from 3 to 7) can switch a net inhibition of PC to a net excitation. Measurements of EPSCs and IPSCs during bursts and modeling showed that this feature can be explained by the interplay between short-term dynamics of the GrC-MLI-PC pathway and E/I balance impinging on PC. Our findings demonstrate that PC firing rate is highly sensitive to the duration of GrC bursts, which may define a temporal-to-rate code transformation in the cerebellar cortex.

Place, publisher, year, edition, pages
SOC NEUROSCIENCE , 2018. Vol. 38, no 22, p. 5153-5167
Keywords [en]
excitation-inhibition balance, burst coding, feedforward inhibition, Purkinje cell, short-term dynamics
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:kth:diva-231736DOI: 10.1523/JNEUROSCI.3270-17.2018ISI: 000435410700011PubMedID: 29720550OAI: oai:DiVA.org:kth-231736DiVA, id: diva2:1230390
Note

QC 20180703

Available from: 2018-07-03 Created: 2018-07-03 Last updated: 2018-07-03Bibliographically approved

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Kumar, Arvind

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