Industrial utilization of tin-initiated resorbable polymers: synthesis on a large scale with a low amount of initiator residue
2007 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 8, no 3, 937-940 p.Article in journal (Refereed) Published
This article presents the successful large-batch synthesis of a resorbable polymer with a minimal amount of residual tin. Ring-opening polymerization of ε-caprolactone was performed in toluene, with a tin (IV) alkoxide as the initiator. A number of parameters were varied in order to study the polymerization with respect to the purity of solvent, batch size, and the residual amount of tin in the polymers. The synthesis of ε-caprolactone in undistilled toluene with 1-di-n-butyl-1-stanna-2,5-dioxacyclopentane as the initiator was successfully performed in batches of 5, 20, and 50 g with no differences in the final conversion, molecular weight, or molecular-weight distribution. The residual amount of tin was significantly reduced from over 1000 to 23 ppm. This study examines the industrial utility of the materials regarding the size and purity of the synthesis.
Place, publisher, year, edition, pages
2007. Vol. 8, no 3, 937-940 p.
Initiators (chemical), Molecular weight distribution, Polycaprolactone, Ring opening polymerization, Solvents, Synthesis (chemical), Tin, Toluene
IdentifiersURN: urn:nbn:se:kth:diva-7344DOI: 10.1021/bm0611331ISI: 000244798600023ScopusID: 2-s2.0-33947695273OAI: oai:DiVA.org:kth-7344DiVA: diva2:12333
QC 201009202007-06-202007-06-202010-09-20Bibliographically approved