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PlanHab(*): hypoxia does not worsen the impairment of skeletal muscle oxidative function induced by bed rest alone
Univ Udine, Dept Med, Piazzale M Kolbe 4, I-33100 Udine, Italy..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Environmental Physiology. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Swedish Aerospace Physiology Centre, SAPC.ORCID iD: 0000-0002-7440-2171
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Environmental Physiology. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Swedish Aerospace Physiology Centre, SAPC.
Univ Pavia, Dept Mol Med, Pavia, Italy..ORCID iD: 0000-0003-1048-0573
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2018 (English)In: Journal of Physiology, ISSN 0022-3751, E-ISSN 1469-7793, Vol. 596, no 15, p. 3341-3355Article in journal (Refereed) Published
Abstract [en]

Skeletal muscle oxidative function was evaluated in 11 healthy males (mean +/- SD age 27 +/- 5years) prior to (baseline data collection, BDC) and following a 21day horizontal bed rest (BR), carried out in normoxia (P-IO2=133 mmHg; N-BR) and hypoxia (P-IO2=90 mmHg; H-BR). H-BR was aimed at simulating reduced gravity habitats. The effects of a 21day hypoxic ambulatory confinement (P-IO2=90 mmHg; H-AMB) were also assessed. Pulmonary O-2 uptake (<(V) over dot>O-2), vastus lateralis fractional O-2 extraction (changes in deoxygenated haemoglobin+myoglobin concentration, Delta[deoxy(Hb+Mb)]; near-infrared spectroscopy) and femoral artery blood flow (ultrasound Doppler) were evaluated during incremental one-leg knee-extension exercise (reduced constraints to cardiovascular O-2 delivery) carried out to voluntary exhaustion in a normoxic environment. Mitochondrial respiration was evaluated ex vivo by high-resolution respirometry in permeabilized vastus lateralis fibres. <(V) over dot>(O2peak) decreased (P<0.05) after N-BR (0.98 +/- 0.13 L min(-1)) and H-BR (0.96 +/- 0.17 L min(-1)) vs. BDC (1.05 +/- 0.14 L min(-1)). In the presence of a decreased (by similar to 6-8%) thigh muscle volume, <(V) over dot>(O2peak) normalized per unit of muscle mass was not affected by both interventions. Delta[deoxy(Hb+Mb)](peak) decreased (P<0.05) after N-BR (65 +/- 13% of limb ischaemia) and H-BR (62 +/- 12%) vs. BDC (73 +/- 13%). H-AMB did not alter <(V) over dot>(O2peak) or Delta[deoxy(Hb+Mb)](peak). An overshoot of Delta[deoxy(Hb+Mb)] was evident during the first minute of unloaded exercise after N-BR and H-BR. Arterial blood flow to the lower limb during both unloaded and peak knee extension was not affected by any intervention. Maximal ADP-stimulated mitochondrial respiration decreased (P<0.05) after all interventions vs. control. In 21day N-BR, a significant impairment of oxidative metabolism occurred downstream of cardiovascular O-2 delivery, affecting both mitochondrial respiration and presumably the intramuscular matching between O-2 supply and utilization. Superposition of H on BR did not worsen the impairment induced by BR alone.

Place, publisher, year, edition, pages
Wiley , 2018. Vol. 596, no 15, p. 3341-3355
Keywords [en]
planetary habitats, microgravity, hypoxia, mitochondrial respiration, skeletal muscle oxidative metabolism
National Category
Neurology
Identifiers
URN: urn:nbn:se:kth:diva-233287DOI: 10.1113/JP275605ISI: 000440417400042PubMedID: 29665013Scopus ID: 2-s2.0-85045726384OAI: oai:DiVA.org:kth-233287DiVA, id: diva2:1240404
Funder
EU, FP7, Seventh Framework Programme, 284438
Note

QC 20180821

Available from: 2018-08-21 Created: 2018-08-21 Last updated: 2020-03-09Bibliographically approved

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Keramidas, Michail E.Eiken, Ola

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