A Disposable Lab-on-a-chip Platform with Embedded Fluid Actuators for Active Nanoliter Liquid Handling
2007 (English)In: Biomedical microdevices (Print), ISSN 1387-2176, E-ISSN 1572-8781, Vol. 9, no 1, 61-67 p.Article in journal (Refereed) Published
In this work we present the development of a disposable liquid handling lab-on-a-chip (LOC) platform with embedded actuators for applications in analytical chemistry. The proposed platform for nanoliter liquid handling is based on a thermally responsive silicone elastomer composite, consisting of PDMS and expandable microspheres. In our LOC platform, we integrate active dosing, transportation and merging of nanoliter liquid volumes. The disposable platform successfully demonstrates precise sample volume control with smart microfluidic manipulation and on-chip active microfluidic components. It is entirely fabricated from low-cost materials using wafer-level processing. Moreover, an enzymatic reaction and real-time detection was successfully conducted to exemplify its applicability as an LOC.
Place, publisher, year, edition, pages
2007. Vol. 9, no 1, 61-67 p.
Biochip; Lab-on-a-chip; Microfluidics; Micropump; PDMS composite; Chemical analysis; Elastomers; Enzyme kinetics; Microactuators; Fluidic devices; dimeticone; microsphere; silastic; accuracy; article; biochip; composite material; controlled study; cost; disposable equipment; enzyme mechanism; equipment design; laboratory test; microfluidic analysis; microfluidics; priority journal; Chemistry, Analytical; Disposable Equipment; Equipment Design; Equipment Failure Analysis; Microchemistry; Microfluidic Analytical Techniques; Nanotechnology; Solutions; Specimen Handling
Other Electrical Engineering, Electronic Engineering, Information Engineering
IdentifiersURN: urn:nbn:se:kth:diva-7398DOI: 10.1007/s10544-006-9015-5ISI: 000243256000008PubMedID: 17106636ScopusID: 2-s2.0-33845986752OAI: oai:DiVA.org:kth-7398DiVA: diva2:12414
QC 201008172007-08-212007-08-212012-03-21Bibliographically approved