Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial
Univ Bergen, Inst Clin Dent, Bergen, Norway..
Univ Bergen, Inst Clin Dent, Bergen, Norway..
Univ Bergen, Inst Clin Dent, Bergen, Norway..
Ulm Univ, Inst Transfus Med, Ulm, Germany.;Univ Hosp Ulm, Inst Clin Transfus Med & Immunogenet Ulm, Red Cross Blood Serv Baden Wurttemberg Hessen, Ulm, Germany.;Univ Hosp Ulm, Inst Transfus Med, Ulm, Germany..
Show others and affiliations
2018 (English)In: Stem Cell Research & Therapy, E-ISSN 1757-6512, Vol. 9, article id 213Article in journal (Refereed) Published
Abstract [en]

Background: Autologous grafting, despite some disadvantages, is still considered the gold standard for reconstruction of maxillofacial bone defects. The aim of this study was to evaluate bone regeneration using bone marrow-derived mesenchymal stromal cells (MSCs) in a clinical trial, a less invasive approach than autologous bone grafting. This comprehensive clinical trial included subjects with severe mandibular ridge resorption. Methods: The study included 11 subjects aged 52-79 years with severe mandibular ridge resorption. Bone marrow cells were aspirated from the posterior iliac crest and plastic adherent cells were expanded in culture medium containing human platelet lysate. The MSCs and biphasic calcium phosphate granules as scaffolds were inserted subperiosteally onto the resorbed alveolar ridge. After 4-6 months of healing, new bone formation was assessed clinically and radiographically, as were safety and feasibility. Bone at the implant site was biopsied for micro computed topography and histological analyses and dental implants were placed in the newly regenerated bone. Functional outcomes and patient satisfaction were assessed after 12 months. Results: The bone marrow cells, expanded in vitro and inserted into the defect together with biphasic calcium phosphate granules, induced significant new bone formation. The regenerated bone volume was adequate for dental implant installation. Healing was uneventful, without adverse events. The patients were satisfied with the esthetic and functional outcomes. No side effects were observed. Conclusions: The results of this comprehensive clinical trial in human subjects confirm that MSCs can successfully induce significant formation of new bone, with no untoward sequelae. Hence, this novel augmentation procedure warrants further investigation and may form the basis of a valid treatment protocol, challenging the current gold standard.

Place, publisher, year, edition, pages
BMC , 2018. Vol. 9, article id 213
Keywords [en]
Bone tissue engineering, Biphasic calcium phosphate, Dental implants, Alveolar ridge augmentation, Mesenchymal stem cells, Bone regeneration
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-233599DOI: 10.1186/s13287-018-0951-9ISI: 000441121200007PubMedID: 30092840Scopus ID: 2-s2.0-85051277681OAI: oai:DiVA.org:kth-233599DiVA, id: diva2:1242090
Note

QC 20180827

Available from: 2018-08-27 Created: 2018-08-27 Last updated: 2018-08-27Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Yassin, Mohammed Ahmed
By organisation
Fibre- and Polymer Technology
In the same journal
Stem Cell Research & Therapy
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 20 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf