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Initial in-vitro trial for intra-cranial pressure monitoring using subdermal proximity-coupled split-ring resonator
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2018 (English)In: IMBioc 2018 - 2018 IEEE/MTT-S International Microwave Biomedical Conference, Institute of Electrical and Electronics Engineers (IEEE), 2018, p. 73-75, article id 8428854Conference paper, Published paper (Refereed)
Abstract [en]

Intra cranial pressure (ICP) monitoring is used in treating severe traumatic brain injury (TBI) patients. All current clinical available measurement methods are invasive presenting considerable social costs. This paper presents a preliminary investigation of the feasibility of ICP monitoring using an innovative microwave-based non-invasive approach. A phantom mimicking the dielectric characteristics of human tissues of the upper part of the head at low microwave frequencies is employed together to a proof-of-concept prototype based on the proposed approach consisting in a readout system and a sub-dermally implanted passive device, both based in split ring resonator techniques. This study shows the potential of our approach to detect two opposite pressure variation stages inside the skull. The employed phantom model needs to be improved to support finer variations in the pressure and better phantom parts, principally for the skull mimic and the loss tangent of all mimics.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2018. p. 73-75, article id 8428854
Keywords [en]
Biocompatible, Intra cranial pressure, Microwave technique, Split ring resonator (SRR) sensor
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-234095DOI: 10.1109/IMBIOC.2018.8428854ISI: 000502126700102Scopus ID: 2-s2.0-85052400710ISBN: 9781538659182 (print)OAI: oai:DiVA.org:kth-234095DiVA, id: diva2:1245592
Conference
2018 IEEE/MTT-S International Microwave Biomedical Conference, IMBioc 2018, Pennsylvania Convention CenterPhiladelphia, United States, 14 June 2018 through 15 June 2018
Note

QC 20180905

Available from: 2018-09-05 Created: 2018-09-05 Last updated: 2020-01-03Bibliographically approved
In thesis
1. Flexible and Stretchable Biointerfacing for Healthcare Diagnostics
Open this publication in new window or tab >>Flexible and Stretchable Biointerfacing for Healthcare Diagnostics
2019 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

Flexible and stretchable wearable biomedical devices provide a platform for continues long-term monitoring of biological signals during neutral body movements thus enabling early intervention and diagnostics of various diseases. This thesis evaluates novel flexible and stretchable bio interfacing medical devices based on microneedle patches and split ring resonator for healthcare diagnostics. Flexible and stretchable microneedle patches were realized by integrating a soft polymer substrate with sharp stainless steel microneedles. This was realized using a magnetic assembly technique. Investigations have shown that the flexible microneedle patch can provide conformal and reliable contact with wrinkles and deformations of the skin. In addition, transdermal monitoring of potassium ions using the proposed flexible microneedle patch have been demonstrated by coating the microneedles with a potassium sensing membrane. Ex-vivo test on the microneedle potassium sensor performed on chicken and porcine skin was able to detect change in potassium concentration in the skin. Furthermore, a novel flexible bio-interface spilt ring resonator (SRR) for the monitoring of intera cranial pressure (ICP) is demonstrated. The sensor was fabricated by depositing a 500 nm gold film on a thermoset thiolene epoxy polymer substrate. The flexible sensor was able to clearly detect the pressure variation that might be an indication of increased ICP in the skull. The proposed methodology of heterogeneous integration of hard materials on a soft and flexible substrate demonstrates a first proof of concept of flexible wearable bio-interfacing devices with vastly different material properties with the potential for continuous and real-time health monitoring.

Place, publisher, year, edition, pages
KTH Royal Institute of Technology, 2019. p. 36
Series
TRITA-EECS-AVL ; 2019:22
Keywords
Wearable biointerfacing sensor, flexible and stretchable microneedles patch, wearable microneedles device, health and fitness monitoring, minimally invasive ICP monitoring, bioelectronics
National Category
Engineering and Technology
Research subject
Electrical Engineering
Identifiers
urn:nbn:se:kth:diva-245075 (URN)978-91-7873-128-2 (ISBN)
Presentation
2019-03-27, Q34, Kungliga Tekniska högskolan, Malvinas väg 6, Stockholm, 10:00 (English)
Opponent
Supervisors
Note

QC 20190306

Available from: 2019-03-06 Created: 2019-03-05 Last updated: 2019-10-09Bibliographically approved

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Niklaus, Frank

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