Painless Drug Delivery through Microneedle-based Transdermal Patches featuring Active Infusion
2008 (English)In: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 55, no 3, 1063-1071 p.Article in journal (Refereed) Published
This paper presents the first microneedle-based transdermal patch with integrated active dispensing functionality. The electrically controlled system consists of a low-cost dosing and actuation unit capable of controlled release of liquid in the microliter range at low flow-rates and minimally invasive, side-opened, microneedles. The system was successfully tested in vivo by insulin administration to diabetic rats. Active infusion of insulin at 2 mu l/h was compared to passive, diffusion-driven, delivery. Continuous active infusion caused significantly higher insulin concentrations in blood plasma. After a 3-h delivery period, the insulin concentration was five times larger compared to passive delivery. Consistent with insulin concentrations, actively administered insulin resulted in a significant decrease of blood glucose levels. Additionally, insertion and liquid injection was verified on human skin. This study shows the feasibility of a patch-like system with on-board liquid storage and dispensing capability. The proposed device represents a first step towards painless and convenient administration of macromolecular drugs such as insulin or vaccines.
Place, publisher, year, edition, pages
2008. Vol. 55, no 3, 1063-1071 p.
drug delivery; insulin; intradermal; microneedles; transdermal; HOLLOW MICRONEEDLES; MEMS MATERIALS; IN-VIVO; DEVICES; BIOCOMPATIBILITY; IMMUNIZATION; PENETRATION; TECHNOLOGY; TRANSPORT; FUTURE
Medical Laboratory and Measurements Technologies
IdentifiersURN: urn:nbn:se:kth:diva-7461DOI: 10.1109/TBME.2007.906492ISI: 000253733800023PubMedID: 18334398ScopusID: 2-s2.0-39749199632OAI: oai:DiVA.org:kth-7461DiVA: diva2:12492
QC 201006242007-09-102007-09-102010-08-17Bibliographically approved