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Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome
Minist Publ Hlth, Key Lab Combined Multiorgan Transplantat, Hangzhou, Zhejiang, Peoples R China.;Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Div Hepatobiliary & Pancreat Surg, Dept Surg, Affiliated Hosp 1,Sch Med, Hangzhou, Zhejiang, Peoples R China..
Women & Childrens Hosp Guangxi, Dept Pediat, Nanning, Peoples R China..
KTH, Centres, Science for Life Laboratory, SciLifeLab.
Minist Publ Hlth, Key Lab Combined Multiorgan Transplantat, Hangzhou, Zhejiang, Peoples R China.;Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Div Hepatobiliary & Pancreat Surg, Dept Surg, Affiliated Hosp 1,Sch Med, Hangzhou, Zhejiang, Peoples R China..
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2018 (English)In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 9, article id 1238Article, review/survey (Refereed) Published
Abstract [en]

Previous studies revealed the potential significance of circulating adiponectin levels with respect to the diagnosis and prediction of metabolic syndrome, but uncertainty has been noted across different cohorts. Systematic evaluation was performed for diagnostic accuracy and predictivity of adiponectin variation for metabolic syndrome in enrolled studies including 1,248 and 6,020 subjects, respectively. Adiponectin can identify metabolic syndrome with moderate accuracy (area under the curve = 0.81, 95% CI: 0.77-0.84). Heterogeneity analysis revealed that an increasing index of insulin resistance was independently associated with improving the performance of adiponectin upon metabolic syndrome diagnosis (ratio of diagnostic odds ratio = 3.89, 95% CI: 1.13-13.9). In addition, reductions in adiponectin were associated with increasing metabolic syndrome incidence in a linear dose-response manner. The risk of hypoadiponectinemia with metabolic syndrome was especially increased in men (P < 0.05). Further Mendelian randomization analysis identified that the amplified risk could be attributed to increased susceptibility (up to 7%) to insulin resistance compared with women. In conclusion, adiponectin measurement might have potential benefits in the detection of metabolic syndrome. Factors that affect insulin resistance should be considered for adjustment in future assessments.

Place, publisher, year, edition, pages
FRONTIERS MEDIA SA , 2018. Vol. 9, article id 1238
Keywords [en]
adiponectin, metabolic syndrome, diagnostic accuracy, prediction, meta-analysis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:kth:diva-235575DOI: 10.3389/fphys.2018.01238ISI: 000445060200001Scopus ID: 2-s2.0-85055112800OAI: oai:DiVA.org:kth-235575DiVA, id: diva2:1252247
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QC 20181001

Available from: 2018-10-01 Created: 2018-10-01 Last updated: 2019-03-18Bibliographically approved

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