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Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome
KTH, Centres, Science for Life Laboratory, SciLifeLab.
Univ Helsinki, Heart & Lung Ctr, Div Cardiol, Cent Hosp, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland..
Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden.;Univ Gothenburg, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden..
KTH, Centres, Science for Life Laboratory, SciLifeLab.
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 14200Article in journal (Refereed) Published
Abstract [en]

Non-alcoholic fatty liver disease (NAFLD) is recognized as a liver manifestation of metabolic syndrome, accompanied with excessive fat accumulation in the liver and other vital organs. Ectopic fat accumulation was previously associated with negative effects at the systemic and local level in the human body. Thus, we aimed to identify and assess the predictive capability of novel potential metabolic biomarkers for ectopic fat depots in non-diabetic men with NAFLD, using the inflammation-associated proteome, lipidome and metabolome. Myocardial and hepatic triglycerides were measured with magnetic spectroscopy while function of left ventricle, pericardial and epicardial fat, subcutaneous and visceral adipose tissue were measured with magnetic resonance imaging. Measured ectopic fat depots were profiled and predicted using a Random Forest algorithm, and by estimating the Area Under the Receiver Operating Characteristic curves. We have identified distinct metabolic signatures of fat depots in the liver (TAG50:1, glutamate, diSM18:0 and CE20:3), pericardium (N-palmitoyl-sphinganine, HGF, diSM18:0, glutamate, and TNFSF14), epicardium (sphingomyelin, CE20:3, PC38:3 and TNFSF14), and myocardium (CE20:3, LAPTGF-beta 1, glutamate and glucose). Our analyses highlighted non-invasive biomarkers that accurately predict ectopic fat depots, and reflect their distinct metabolic signatures in subjects with NAFLD.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 8, article id 14200
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Medical and Health Sciences
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URN: urn:nbn:se:kth:diva-235879DOI: 10.1038/s41598-018-31865-wISI: 000445276000044PubMedID: 30242179Scopus ID: 2-s2.0-85053722070OAI: oai:DiVA.org:kth-235879DiVA, id: diva2:1254183
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20181008

Available from: 2018-10-08 Created: 2018-10-08 Last updated: 2018-10-08Bibliographically approved

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Benfeitas, RuiMardinoglu, Adil

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