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Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis
KTH, School of Engineering Sciences (SCI), Applied Physics, Experimental Biomolecular Physics. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-1850-5440
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2018 (English)In: ACS Chemical Biology, ISSN 1554-8929, E-ISSN 1554-8937, Vol. 13, no 6, p. 1525-1535Article in journal (Refereed) Published
Abstract [en]

The occurrence of autoantibodies is a hallmark of rheumatoid arthritis, specifically those autoantibodies targeting proteins containing the arginine-derived amino acid citrulline. There is strong evidence showing that the occurrence of anticitrullinated protein/peptide antibodies (ACPA) are involved in disease progression, and ACPA was recently shown to induce pain in animals. Here, we explore a novel concept useful for research, diagnostics, and possibly therapy of autoimmune diseases, namely, to directly target and neutralize autoantibodies using peptide binders. A high-affinity peptide-based scavenger of ACPA was developed by grafting a citrullinated epitope derived from human fibrinogen into a naturally occurring stable peptide scaffold. The best scavenger comprises the truncated epitope α-fibrinogen, [Cit573]fib(566-580), grafted into the scaffold sunflower trypsin inhibitor-1, SFTI-1. The final peptide demonstrates low nanomolar apparent affinity and superior stability.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2018. Vol. 13, no 6, p. 1525-1535
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-238191DOI: 10.1021/acschembio.8b00118ISI: 000435746200015PubMedID: 29630823Scopus ID: 2-s2.0-85048723009OAI: oai:DiVA.org:kth-238191DiVA, id: diva2:1264344
Funder
Stockholm County CouncilSwedish Research Council, 2017-02577, 2012-5063Swedish Foundation for Strategic Research , F06-0058The Karolinska Institutet's Research FoundationSwedish Rheumatism AssociationScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20181120

Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2018-11-20Bibliographically approved

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Wennmalm, Stefan

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