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Ultrasonic Based Tissue Modelling and Engineering
KTH, School of Engineering Sciences (SCI), Applied Physics.ORCID iD: 0000-0002-3976-3430
KTH, School of Engineering Sciences (SCI), Applied Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics.
2018 (English)In: Micromachines, ISSN 2072-666X, E-ISSN 2072-666X, Vol. 9, no 11, article id 594Article, review/survey (Refereed) Published
Abstract [en]

Systems and devices for in vitro tissue modelling and engineering are valuable tools, which combine the strength between the controlled laboratory environment and the complex tissue organization and environment in vivo. Device-based tissue engineering is also a possible avenue for future explant culture in regenerative medicine. The most fundamental requirements on platforms intended for tissue modelling and engineering are their ability to shape and maintain cell aggregates over long-term culture. An emerging technology for tissue shaping and culture is ultrasonic standing wave (USW) particle manipulation, which offers label-free and gentle positioning and aggregation of cells. The pressure nodes defined by the USW, where cells are trapped in most cases, are stable over time and can be both static and dynamic depending on actuation schemes. In this review article, we highlight the potential of USW cell manipulation as a tool for tissue modelling and engineering.

Place, publisher, year, edition, pages
MDPI , 2018. Vol. 9, no 11, article id 594
Keywords [en]
acoustic trapping, ultrasonic manipulation, tissue engineering, tissue modelling, acoustofluidics, microfluidics
National Category
Physical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-240005DOI: 10.3390/mi9110594ISI: 000451314900057PubMedID: 30441752Scopus ID: 2-s2.0-85057017318OAI: oai:DiVA.org:kth-240005DiVA, id: diva2:1269327
Note

QC 20181210

Available from: 2018-12-10 Created: 2018-12-10 Last updated: 2018-12-10Bibliographically approved

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Olofsson, KarlWiklund, Martin

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