Software sensors for fermentation processes
2008 (English)In: Bioprocess and biosystems engineering (Print), ISSN 1615-7591, E-ISSN 1615-7605, Vol. 31, no 2, 145-152 p.Article in journal (Refereed) Published
Four software sensors based on standard on-line data from fermentation processes and simple mathematical models were used to monitor a number of state variables in Escherichia coli fed-batch processes: the biomass concentration, the specific growth rate, the oxygen transfer capacity of the bioreactor, and the new R-O/S sensor which is the ratio between oxygen and energy substrate consumption. The R-O/S variable grows continuously in a fed-batch culture with constant glucose feed, which reflects the increasing maintenance demand at declining specific growth rate. The R-O/S sensor also responded to rapid pH shift-downs reflecting the increasing demand for maintenance energy. It is suggested that this sensor may be used to monitor the extent of physiological stress that demands energy for survival.
Place, publisher, year, edition, pages
2008. Vol. 31, no 2, 145-152 p.
Biomass; Growth rate; Oxygen transfer; Process analytical technology (PAT); Software sensor; Stress; Biomass; Bioreactors; Fermentation; Growth rate; Mathematical models; Software architecture; Fed-batch culture; Oxygen transfer; Process analytical technology (PAT); Software sensors; Biosensors; article; bacterial cell; bacterium culture; biomass; bioreactor; computer program; controlled study; cytolysis; Escherichia coli; fermentation; nonhuman; priority journal; viscosity; Algorithms; Bioreactors; Cell Proliferation; Computer Simulation; Escherichia coli; Escherichia coli Proteins; Fermentation; Models, Biological; Oxygen; Software
Other Industrial Biotechnology
IdentifiersURN: urn:nbn:se:kth:diva-7622DOI: 10.1007/s00449-007-0157-5ISI: 000252467200012PubMedID: 17726584ScopusID: 2-s2.0-38349147666OAI: oai:DiVA.org:kth-7622DiVA: diva2:12706
QC 201008192007-11-122007-11-122010-08-19Bibliographically approved