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Exploring the autoantibody repertoire in patients with obsessive compulsive disorder
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science. (Affinity Proteomics)ORCID iD: 0000-0001-6126-2256
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Affinity Proteomics.ORCID iD: 0000-0002-0056-1313
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Affinity Proteomics.ORCID iD: 0000-0003-1363-5796
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(English)Manuscript (preprint) (Other academic)
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-241045OAI: oai:DiVA.org:kth-241045DiVA, id: diva2:1275779
Note

QC 20190108

Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-01-08Bibliographically approved
In thesis
1. On the profiling of autoantibodies in psychiatric disorders
Open this publication in new window or tab >>On the profiling of autoantibodies in psychiatric disorders
2019 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

There is a great need to increase our understanding of diseases affecting the brain and their underlying pathogenic mechanisms. To address this need, the work presented in this thesis applied affinity based proteomic techniques to profile proteins, and to investigate protein profiles and the autoantibody repertoire in brain related disorders. Studies included in this thesis cover traumatic brain injuries, first-episode psychosis, schizophrenia and obsessive-compulsive disorders. Paper I describes the profiling of rat serum samples of a traumatic brain injury model to increase the understanding of injury related protein markers and their potential role in patient outcome. Changes in protein profiles over time were characterized as well as potential injury markers related to oxygen intake. Paper II-IV describe the use of protein fragment-based arrays to investigate potential pathogenic autoantibodies associated to the disease. In Paper II possible predictive autoantibodies for the development of schizophrenia were identified, Paper III identified probable brain reactive autoantibodies in schizophrenia patients and Paper IV described the exploration of autoantibodies which might have an association to obsessive-compulsive disorder. Further characterization of these autoantibody repertoires in psychiatric disorders and future efforts could increase our understanding of their role in the associated diseases. Taken together, this work provides the basis for future research in the search for novel disease associated proteins and autoantibody profiles in brain related disorders. An increased understanding and additional diagnostic or prognostic markers of these disorders would be beneficial for both researchers and patients.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2019
Series
TRITA-CBH-FOU ; 2019:3
Keywords
affinity proteomics, microarrays, suspension bead array, autoantibodies, autoimmunity, psychiatric disorders, schizophrenia
National Category
Medical Biotechnology
Identifiers
urn:nbn:se:kth:diva-241047 (URN)978-91-7873-075-9 (ISBN)
Public defence
2019-02-08, Atrium, Nobelsväg 12B, Stockholm, 10:00 (English)
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Note

QC 20180108

Available from: 2019-01-08 Created: 2019-01-07 Last updated: 2019-01-08Bibliographically approved

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Just, DavidNilsson, Peter

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