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Damage in vascular tissues and its modeling
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.).
2017 (English)In: CISM International Centre for Mechanical Sciences, Courses and Lectures, Springer International Publishing , 2017, p. 85-118Chapter in book (Refereed)
Abstract [en]

The present chapter reviews vessel wall histology and summarizes relevant continuum mechanical concepts to study mechanics-induced tissue damage. As long as the accumulated damage does not trigger strain localizations, the standard nonpolar continuum mechanical framework is applicable. As an example, a damage model for collagenous tissue is discussed and used to predict collagen damage in the aneurysm wall at supra-physiologic loading. The physical meaning of model parameters allow their straight forward identification from independent mechanical and histological experimental data. In contrast, if damage accumulates until the material’s stiffness looses its strong ellipticity, more advanced continuum mechanical approaches are required. Specifically, modeling vascular failure by a fracture process zone is discussed, such that initialization and coalescence of micro-defects is mechanically represented by a phenomenological cohesive traction separation law. Failure of ventricular tissue due to deep penetration illustrates the applicability of the model. Besides appropriate continuum mechanical approaches, laboratory experiments that are sensitive to constitutive model parameters and ensure controlled failure propagation are crucial for a robust parameter identification of failure models. 

Place, publisher, year, edition, pages
Springer International Publishing , 2017. p. 85-118
Keywords [en]
Cohesive Traction, Cohesive Zone, Collagen Fiber, Collagen Fibril, Fracture Process Zone
National Category
Mechanical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-236814DOI: 10.1007/978-3-319-45071-1_4Scopus ID: 2-s2.0-85051259154OAI: oai:DiVA.org:kth-236814DiVA, id: diva2:1275894
Note

QC 20190107

Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-01-07Bibliographically approved

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Gasser, T. Christian

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  • apa
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