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Dynamics of testosterone levels in patients with newly detected glucose abnormalities and acute myocardial infarction
Karolinska Inst, Div Cardiol, Dept Med, S-17176 Stockholm, Sweden..
Karolinska Inst, Dept Med, Ctr Androl & Sexual Med, Huddinge, Sweden..
Karolinska Inst, Dept Med, Ctr Androl & Sexual Med, Huddinge, Sweden..
Karolinska Inst, Div Cardiol, Dept Med, S-17176 Stockholm, Sweden.;Karolinska Inst, Dept Neurobiol, Ctr Family Med Care Sci & Soc, Huddinge, Sweden..
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2018 (English)In: Diabetes & Vascular Disease Research, ISSN 1479-1641, E-ISSN 1752-8984, Vol. 15, no 6, p. 511-518Article in journal (Refereed) Published
Abstract [en]

Objective: Low testosterone has been associated with increased cardiovascular risk and glucose abnormalities. This study explored the prevalence of low testosterone, dynamics over time and prognostic implications in acute myocardial infarction patients with or without glucose abnormalities. Methods: Male acute myocardial infarction patients (n = 123) and healthy controls (n = 124) were categorised as having normal or abnormal glucose tolerance (impaired glucose tolerance or diabetes) by oral glucose tolerance testing. Testosterone was measured at hospital admission, discharge, 3 and 12 months thereafter in patients. Patients and controls were followed for 11 years for major cardiovascular events (cardiovascular death/acute myocardial infarction/stroke/severe heart failure). Results: At hospital admission, more patients had low testosterone (<= 300 ng/dl) and lower median levels than controls (64 vs 28%; p < 0.001 and 243 vs 380 ng/dl; p < 0.01). At the subsequent time points, testosterone had increased to 311, 345 and 357 ng/dl. Patients with abnormal glucose tolerance had the highest prevalence (75%) of low levels. In adjusted Cox regression models, neither total nor free testosterone predicted major cardiovascular events. Conclusion: Low testosterone levels were common in male acute myocardial infarction patients in the acute phase, especially in the presence of abnormal glucose tolerance, but increased over time indicating that testosterone measured in close proximity to acute myocardial infarction should be interpreted with caution.

Place, publisher, year, edition, pages
Sage Publications, 2018. Vol. 15, no 6, p. 511-518
Keywords [en]
Testosterone, diabetes mellitus type 2, glucose intolerance, prediabetic state, myocardial infarction, prognosis
National Category
Health Sciences
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URN: urn:nbn:se:kth:diva-239792DOI: 10.1177/1479164118802543ISI: 000450313700005PubMedID: 30280926Scopus ID: 2-s2.0-85056343096OAI: oai:DiVA.org:kth-239792DiVA, id: diva2:1276651
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QC 20190108

Available from: 2019-01-08 Created: 2019-01-08 Last updated: 2019-01-17Bibliographically approved

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