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A novel cysteine-linked antibacterial surface coating significantly inhibits bacterial colonization of nasal silicone prongs in a phase one pre-clinical trial
KTH, Centres, Science for Life Laboratory, SciLifeLab. CytaCoat AB, Stockholm, Sweden.;Karolinska Inst, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Ctr Hematol, Stockholm, Sweden..ORCID iD: 0000-0003-0996-1644
CytaCoat AB, Stockholm, Sweden..
CytaCoat AB, Stockholm, Sweden..
Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
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2018 (English)In: Materials science & engineering. C, biomimetic materials, sensors and systems, ISSN 0928-4931, E-ISSN 1873-0191, Vol. 93, p. 782-789Article in journal (Refereed) Published
Abstract [en]

Ventilator associated pneumonia and sepsis are frequent complications in neonatal care. Bacterial colonization of medical devices and interfaces used for respiratory support may contribute by functioning as a bacterial reservoir seeding bacteria into airways. We have developed an antibacterial surface coating based on a cysteine ligand covalently coupled via a spacer to a carboxylic backbone layer on an acrylic acid grafted silicone surface. This coating was applied on a commercially available nasal prong and the antibacterial effect was evaluated both in vitro and in vivo in a first-in-human phase 1 trial. The coated nasal prongs had strong antibacterial activity against both Gram-negative and Gram-positive bacteria in vitro. In a randomized pre-clinical trial study of 24 + 24 healthy adult volunteers who carried coated or non-coated nasal prongs for 18 h, a (10)log difference in mean bacterial colonization of 5.82 (p < 0.0001) was observed. These results show that this coating technique can prevent colonization by the normal skin and mucosal flora, and thus represent a promising novel technology for reduction of medical device-associated hospital acquired infections.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2018. Vol. 93, p. 782-789
Keywords [en]
Antibacterial coating, Cysteine ligand, Covalent binding, Phase one trial
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:kth:diva-238107DOI: 10.1016/j.msec.2018.08.040ISI: 000447569400075PubMedID: 30274112Scopus ID: 2-s2.0-85052192588OAI: oai:DiVA.org:kth-238107DiVA, id: diva2:1277569
Note

QC 20190110

Available from: 2019-01-10 Created: 2019-01-10 Last updated: 2019-01-10Bibliographically approved

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Odeberg, Jacob

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