Covalent Grafting of Poly(L-lactide) to Tune the In Vitro Degradation Rate
2007 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 8, no 8, 2492-2496 p.Article in journal (Refereed) Published
The in vitro rate of degradation was purposely affected by covalently grafting the surface of poly(L-lactide) (PLLA). PLLA films were surface modified by our vapor-phase nondestructive photografting technique. Films were grafted for 20 min with one of the following monomers: acryl amide (AAm), N-vinyl pyrrolidone (VP), or acrylic acid (AA) and thereafter incubated in vitro in a phosphate-buffered saline solution at 37 C for 154 days. The films were studied with contact angle measurements, SEM, ATR-FTIR, SEC, and DSC. The analyses verified that the in vitro rate of degradation was enhanced and that the grafted surface layer did remain covalently attached to the surface during the initial stages of incubation.
Place, publisher, year, edition, pages
2007. Vol. 8, no 8, 2492-2496 p.
Contact angle; Degradation; Differential scanning calorimetry; Fourier transform infrared spectroscopy; Grafting (chemical); Scanning electron microscopy; Surface treatment; Covalent grafting; Degradation rate; In vitro degradation; Polylactide; Biopolymers; 1 vinyl 2 pyrrolidinone; acrylamide; acrylic acid; phosphate buffered saline; polylactide; article; Fourier transform mass spectrometry; gel permeation chromatography; in vitro study; photodegradation; priority journal; protein degradation; scanning electron microscopy; temperature dependence; Acrylamide; Acrylates; Calorimetry, Differential Scanning; Microscopy, Electron, Scanning; Phosphates; Polyesters; Pyrrolidinones; Spectroscopy, Fourier Transform Infrared; Surface Properties
IdentifiersURN: urn:nbn:se:kth:diva-7679DOI: 10.1021/bm700442jISI: 000248755000021PubMedID: 17630795ScopusID: 2-s2.0-34548275104OAI: oai:DiVA.org:kth-7679DiVA: diva2:12777
QC 201008042007-11-202007-11-202010-08-04Bibliographically approved