Surface Functionalization of Porous Resorbable Scaffolds by Covalent Grafting
2008 (English)In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 8, no 7, 645-654 p.Article in journal (Refereed) Published
Resorbable porous scaffold discs and solid films were prepared from poly[(1,5-dioxepan-2one)-co-(L-lactide)] and poly [(epsilon-caprolactone)-co-(L-lactide)]. The surfaces of the scaffolds were functionalized to increase their hydrophilicity. A total of 90 samples were prepared to cover all important combinations of experimental and material factors, and all experimental data were fitted by a partial least square model. As a result of grafting, the porous discs and solid films exhibited a tremendous increase in wettability. The functionalized discs were hygroscopic so that water was instantly absorbed and thoroughly wet the substrates.
Place, publisher, year, edition, pages
2008. Vol. 8, no 7, 645-654 p.
Biocompatibility; Functionalization of polymers; Grafting; Scaffolds; Surface modification; ABS resins; Biocompatibility; Curve fitting; Film preparation; Functional polymers; Grafting (chemical); Ketones; Surfaces; Caprolactone; Covalent grafting; Experimental datum; Functionalization of polymers; Functionalized; Grafting; Lactide; Material factors; Partial least square models; Porous scaffolds; Solid films; Surface functionalization; Surface modification; 1, 5 benzodioxepane derivative; molecular scaffold; polycaprolactone; polylactide; lactide caprolactone copolymer; lactide-caprolactone copolymer; polyester; water; article; chemical binding; controlled study; covalent grafting; hydrophilicity; partial least squares regression; porosity; surface property; water absorption; wettability; absorption; chemistry; hydrophobicity; Absorption; Hydrophobicity; Polyesters; Porosity; Water; Wettability
IdentifiersURN: urn:nbn:se:kth:diva-7680DOI: 10.1002/mabi.200700329ISI: 000257817300006PubMedID: 18383572ScopusID: 2-s2.0-54049136569OAI: oai:DiVA.org:kth-7680DiVA: diva2:12778
QC 20100804. Uppdaterad från Submitted till Published 20100804.2007-11-202007-11-202010-08-04Bibliographically approved