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Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
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2018 (English)In: JACC: Basic to Translational Science, ISSN 2452-302X, Vol. 3, no 4, p. 464-480Article in journal (Refereed) Published
Abstract [en]

Clinical tools to identify individuals with unstable atherosclerotic lesions are required to improve prevention of myocardial infarction and ischemic stroke. Here, a systems-based analysis of atherosclerotic plaques and plasma from patients undergoing carotid endarterectomy for stroke prevention was used to identify molecular signatures with a causal relationship to disease. Local plasma collected in the lesion proximity following clamping prior to arteriotomy was profiled together with matched peripheral plasma. This translational workflow identified biliverdin reductase B as a novel marker of intraplaque hemorrhage and unstable carotid atherosclerosis, which should be investigated as a potential predictive biomarker for cardiovascular events in larger cohorts.

Place, publisher, year, edition, pages
2018. Vol. 3, no 4, p. 464-480
Keywords [en]
atherosclerosis, biomarkers, intraplaque hemorrhage, omics analyses, translational studies
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:kth:diva-238051DOI: 10.1016/j.jacbts.2018.04.001Scopus ID: 2-s2.0-85053830575OAI: oai:DiVA.org:kth-238051DiVA, id: diva2:1278838
Note

Export Date: 30 October 2018; Article; Correspondence Address: Hedin, U.; Department of Molecular Medicine and Surgery, L8:03, Karolinska Institute, Sweden; email: Ulf.Hedin@ki.se

QC 20190115

Available from: 2019-01-15 Created: 2019-01-15 Last updated: 2019-01-21Bibliographically approved

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Iglesias, Maria JesusHong, Mun-GwanSanchez-Rivera, LauraUhlén, MathiasSchwenk, Jochen M.Odeberg, Jacob

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Iglesias, Maria JesusHong, Mun-GwanSanchez-Rivera, LauraUhlén, MathiasSchwenk, Jochen M.Odeberg, Jacob
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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
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  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
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