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Human cytomegalovirus replication induces endothelial cell interleukin-11
KTH, Centres, Science for Life Laboratory, SciLifeLab.
2018 (English)In: Cytokine, ISSN 1043-4666, E-ISSN 1096-0023, Vol. 111, p. 563-566Article in journal (Refereed) Published
Abstract [en]

Endothelial cells (EC) are critical sites of human cytomegalovirus (hCMV) infection in vivo. Infection can induce the production of various EC cytokines, such as interleukin (IL-)6, which can have autocrine and/or paracrine effector functions. Here, we report that hCMV induces the production of EC IL-11, a relatively understudied member of the IL-6-type cytokine family. We detail temporal EC IL-11 translation and protein secretion dynamics in response to hCMV infection, and reveal distinct differences compared to EC IL-6. Viral replication had markedly opposing effects on the regulation of these closely related cytokines, representing a major driving force behind IL-11 production, whilst concurrently suppressing IL-6 expression. This is the first report of any biological agent that stimulates EC IL-11 production.

Place, publisher, year, edition, pages
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD , 2018. Vol. 111, p. 563-566
Keywords [en]
Interleukin 11, Interleukin 6, Cytomegalovirus, Endothelial cell
National Category
Immunology
Identifiers
URN: urn:nbn:se:kth:diva-241343DOI: 10.1016/j.cyto.2018.05.018ISI: 000454753800075PubMedID: 29807687Scopus ID: 2-s2.0-85047466656OAI: oai:DiVA.org:kth-241343DiVA, id: diva2:1280792
Note

QC 20190121

Available from: 2019-01-21 Created: 2019-01-21 Last updated: 2019-01-21Bibliographically approved

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