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A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.ORCID iD: 0000-0002-9637-970X
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.
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2018 (English)In: Contrast Media & Molecular Imaging, ISSN 1555-4309, E-ISSN 1555-4317, article id UNSP 8174820Article in journal (Refereed) Published
Abstract [en]

Nanoparticles (NPs) have been used as contrast agents for several bioimaging modalities. X-ray fluorescence (XRF) tomography can provide sensitive and quantitative 3D detection of NPs. With spectrally matched NPs as contrast agents, we demonstrated earlier in a laboratory system that XRF tomography could achieve high-spatial-resolution tumor imaging in mice. Here, we present the synthesis, characterization, and evaluation of a library of NPs containing Y, Zr, Nb, Rh, and Ru that have spectrally matched K-shell absorption for the laboratory scale X-ray source. The K-shell emissions of these NPs are spectrally well separated from the X-ray probe and the Compton background, making them suitable for the lab-scale XRF tomography system. Their potential as XRF contrast agents is demonstrated successfully in a small-animal equivalent phantom, confirming the simulation results. The diversity in the NP composition provides a flexible platform for a better design and biological optimization of XRF tomography nanoprobes.

Place, publisher, year, edition, pages
WILEY-HINDAWI , 2018. article id UNSP 8174820
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Radiology, Nuclear Medicine and Medical Imaging
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URN: urn:nbn:se:kth:diva-242269DOI: 10.1155/2018/8174820ISI: 000455608200001Scopus ID: 2-s2.0-85059939967OAI: oai:DiVA.org:kth-242269DiVA, id: diva2:1284931
Note

QC 20190201

Available from: 2019-02-01 Created: 2019-02-01 Last updated: 2019-08-20Bibliographically approved

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Larsson, Jakob C.Vogt, Carmen

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