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Oxygen Management at the Microscale: A Functional Biochip Material with Long-Lasting and Tunable Oxygen Scavenging Properties for Cell Culture Applications
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2019 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 11, no 10, p. 9730-9739Article in journal (Refereed) Published
Abstract [en]

Oxygen plays a pivotal role in cellular homeostasis, and its partial pressure determines cellular function and fate. Consequently, the ability to control oxygen tension is a critical parameter for recreating physiologically relevant in vitro culture conditions for mammalian cells and microorganisms. Despite its importance, most microdevices and organ-on-a-chip systems to date overlook oxygen gradient parameters because controlling oxygen often requires bulky and expensive external instrumental setups. To overcome this limitation, we have adapted an off-stoichiometric thiol-ene-epoxy polymer to efficiently remove dissolved oxygen to below 1 hPa and also integrated this modified polymer into a functional biochip material. The relevance of using an oxygen scavenging material in microfluidics is that it makes it feasible to readily control oxygen depletion rates inside the biochip by simply changing the surface-to-volume aspect ratio of the microfluidic channel network as well as by changing the temperature and curing times during the fabrication process.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2019. Vol. 11, no 10, p. 9730-9739
Keywords [en]
oxygen control, oxygen scavenging, thiol-ene, functional material, bacteria, mammalian cells
National Category
Textile, Rubber and Polymeric Materials
Identifiers
URN: urn:nbn:se:kth:diva-248344DOI: 10.1021/acsami.8b19641ISI: 000461538000010PubMedID: 30747515Scopus ID: 2-s2.0-85062816786OAI: oai:DiVA.org:kth-248344DiVA, id: diva2:1303342
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QC 20190409

Available from: 2019-04-09 Created: 2019-04-09 Last updated: 2019-04-09Bibliographically approved

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Haraldsson, Klas Tommy

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