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Conjugated Polymers for Assessing and Controlling Biological Functions
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
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2019 (English)In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 31, no 22, article id 1806712Article in journal (Refereed) Published
Abstract [en]

The field of organic bioelectronics is advancing rapidly in the development of materials and devices to precisely monitor and control biological signals. Electronics and biology can interact on multiple levels: organs, complex tissues, cells, cell membranes, proteins, and even small molecules. Compared to traditional electronic materials such as metals and inorganic semiconductors, conjugated polymers (CPs) have several key advantages for biological interactions: tunable physiochemical properties, adjustable form factors, and mixed conductivity (ionic and electronic). Herein, the use of CPs in five biologically oriented research topics, electrophysiology, tissue engineering, drug release, biosensing, and molecular bioelectronics, is discussed. In electrophysiology, implantable devices with CP coating or CP-only electrodes are showing improvements in signal performance and tissue interfaces. CP-based scaffolds supply highly favorable static or even dynamic interfaces for tissue engineering. CPs also enable delivery of drugs through a variety of mechanisms and form factors. For biosensing, CPs offer new possibilities to incorporate biological sensing elements in a conducting matrix. Molecular bioelectronics is today used to incorporate (opto)electronic functions in living tissue. Under each topic, the limits of the utility of CPs are discussed and, overall, the major challenges toward implementation of CPs and their devices to real-world applications are highlighted.

Place, publisher, year, edition, pages
2019. Vol. 31, no 22, article id 1806712
Keywords [en]
biosensors, conjugated polymers, electrophysiology, organic bioelectronics, tissue engineering
National Category
Textile, Rubber and Polymeric Materials
Research subject
Technology and Health
Identifiers
URN: urn:nbn:se:kth:diva-250560DOI: 10.1002/adma.201806712ISI: 000475696300006PubMedID: 30861237Scopus ID: 2-s2.0-85062980044OAI: oai:DiVA.org:kth-250560DiVA, id: diva2:1308066
Funder
EU, Horizon 2020, 797506EU, Horizon 2020, 797777Knut and Alice Wallenberg FoundationThe Royal Swedish Academy of SciencesGöran Gustafsson Foundation for Research in Natural Sciences and Medicine
Note

QC 20190521

Available from: 2019-04-30 Created: 2019-04-30 Last updated: 2019-08-02Bibliographically approved

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The full text will be freely available from 2020-03-13 11:58
Available from 2020-03-13 11:58

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Winkler, ThomasHerland, Anna

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