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AN AUTONOMOUS BLOOD MICROSAMPLING DEVICE ENABLING METERED LARGE-VOLUME DRIED PLASMA SPOTS (DPS)
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.ORCID iD: 0000-0003-3601-0342
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.ORCID iD: 0000-0001-9552-4234
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
2018 (English)Conference paper, Published paper (Other academic)
Abstract [en]

This work introduces a novel principle for volume metering of passively separated blood plasma, empowered by an air pinch-off structure and the high capillary force of a paper matrix. The presented microfluidic device enables the autonomous generation of large-volume dried plasma spots (DPS) with 16 μl of plasma from 50-100 μl of human whole blood within less than 10 minutes. Providing large-volume DPS increases the confidence level of detecting low concentration analytes and constitutes a step towards using blood microsampling in the everyday blood analysis routine.

Place, publisher, year, edition, pages
2018. Vol. 22
National Category
Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:kth:diva-250571OAI: oai:DiVA.org:kth-250571DiVA, id: diva2:1308100
Conference
Twenty Second International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2018)
Note

QC 20190625

Available from: 2019-04-30 Created: 2019-04-30 Last updated: 2019-06-25Bibliographically approved

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Hauser, JanoschStemme, GöranRoxhed, Niclas

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