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Polymer nanoliter well arrays for liquid storage and rapid on-demand electrochemical release
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.ORCID iD: 0000-0001-9651-4900
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.ORCID iD: 0000-0003-4364-794X
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.ORCID iD: 0000-0002-0441-6893
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.ORCID iD: 0000-0001-8248-6670
2018 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, no 267, p. 111-118Article in journal, Editorial material (Refereed) Published
Abstract [en]

Polymer microfluidic systems are of increasing importance in several applications in biomedicine andbiosensing. The integrated encapsulation, storage, and controlled release of small amounts of liquid insuch systems remains an unresolved technical challenge. Here, we report two methods for the room-temperature and adhesive-free sealing of 1–330 nanoliter volumes of liquid in off-stoichiometry thiol-enepolymer well arrays by spontaneous bonding to 200 nm thin gold films. Sealed well arrays were storedfor more than one month in a liquid environment with <10% liquid loss, and for more than one week inair with minimal loss. We demonstrated that controlling the electrical potential and polarity over encap-sulated wells allowed for selecting one of two well opening mechanisms: slow anodic electrochemicaletching, or rapid electrolytic gas pressure-induced bursting of the gold film. The results may find poten-tial applications in diagnostic testing, in vivo drug delivery, or in spatio-temporal release of chemicalcompounds in biological assays.

Place, publisher, year, edition, pages
2018. no 267, p. 111-118
National Category
Nano Technology Other Electrical Engineering, Electronic Engineering, Information Engineering Medical and Health Sciences
Identifiers
URN: urn:nbn:se:kth:diva-250772OAI: oai:DiVA.org:kth-250772DiVA, id: diva2:1313700
Note

QC 20190521

Available from: 2019-05-06 Created: 2019-05-06 Last updated: 2019-05-21Bibliographically approved

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Vastesson, AlexanderGuo, MaoxiangHaraldsson, Klas Tommyvan der Wijngaart, Wouter

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