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A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment
MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA..ORCID iD: 0000-0003-2910-9176
MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Med Sch, Div Gastroenterol Hepatol & Endoscopy, Brigham & Womens Hosp, Boston, MA 02115 USA..
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
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Number of Authors: 492019 (English)In: Science Translational Medicine, ISSN 1946-6234, E-ISSN 1946-6242, Vol. 11, no 483, article id eaau6267Article in journal (Refereed) Published
Abstract [en]

Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.

Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE , 2019. Vol. 11, no 483, article id eaau6267
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Pharmaceutical Sciences
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URN: urn:nbn:se:kth:diva-251298DOI: 10.1126/scitranslmed.aau6267ISI: 000461050500004PubMedID: 30867322Scopus ID: 2-s2.0-85062832588OAI: oai:DiVA.org:kth-251298DiVA, id: diva2:1314666
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QC 20190509

Available from: 2019-05-09 Created: 2019-05-09 Last updated: 2019-05-09Bibliographically approved

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Roxhed, Niclas

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